Curriculum Vitae



Name   Franziska Schädeli Stark
Date of birth   February 6, 1967
Place of birth   Berne (Switzerland)
Citizenship   Switzerland
Places of origin   Kirchlindach, BE, and Zwingen, BL
Marital status   married
Spouse's Name   Robert Stark
Mother tongue   German
Children   Sebastian Timothy (October 17, 2000); Georg Emanuel (June 22, 2002); Klara Lynne (Ocotber 20, 2005)
Address (home)   Baumgartenweg 6, 3063 Ittigen, Switzerland
Phone, email:   ++41 31 991 47 28,
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General Eduation

1974−1978   Primarschule Uettligen (BE)
1978−1983   Sekundarschule Uettligen (BE)
1983−1987   Städtisches Literargymnasium Bern-Neufeld
09/18/1987   Maturity examination
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Pharmaceutical Education and Postgraduate Training

1988−1993   Studies of Pharmacy at the Medical Faculty of the University of Berne, Switzerland
1990−1991   Practical training as a Pharmacist, Rathaus-Apotheke Bern, supervised by Dr.pharm. St. Fritz
1994−1997   Division of Nephrology, Department of Medicine, University of Berne
Curriculum to achieve a PhD degree in pharmacology, supervised by Dominik E. Uehlinger, MD, and Felix J. Frey, MD.
  • Subject: Population pharmacokinetic/-dynamic (PKPD) methods in patients on hemodialysis and in renal transplant recipients. The computer program NONMEM was used for PKPD data analyses.
  • Project 1: Population PK study to assess dosing guidelines for intravenous vancomycin in high-flux hemodialysis: Design, planning and organization of a clinical trial in 26 patients on chronical hemodialysis; development of a HPLC assay to quantify vancomycin serum concentrations; population PK data analysis.
  • Project 2: Clinical trial to compare the pharmacokinetics of two galenic formulas of cyclosporine A (Sandimmune, Sandimmune Neoral) in renal transplant recipients: Design, planning and organization of a clinical trial in renal transplant recipients with population (n=50) and classic study (n=10) design; comparison of population PK modeling with classic non-compartmental data analysis.
08/25/1997   PhD graduate examination in pharmacology and clinical pharmacology
09/29/1997   Defense of the thesis: "Population pharmacokinetic methods in patients on renal replacement therapy: Urea kinetics and dialysis treatment time predict vancomycin elimination during high-flux hemodialysis"
02/1998−01/1999   Swiss National Science Foundation fellowship for prospective researchers at the University of California, San Francisco, (UCSF), USA.
  • Project title: Parametric and semi-parametric models in population pharmacokinetic and pharmacodynamic data analysis using HIV antiretroviral therapy as a model situation
  • Supervisors: Davide Verotta, PhD, and Lewis B. Sheiner, MD
02/1999−01/2000   Extension of the fellowship by UCSF
  • Project 1: Semi-parametric model to describe long-term HIV plasma levels in highly active antiretroviral therapy (HAART): Development of models to describe the non-linearities of viral load observed during HAART. Main objective: to find simple non-linear empirical population models that can predict both long term suppression and rebound of viral load during HAART. Example data of AIDS Clinical Trial Group Protocol 315 were available.
  • Project 2: Influence of arterial vs venous plasma sampling for pharmacodynamic model selection and parameter estimation at the example of nicotine: In a PK/PD link model arterial concentrations were represented either by observed arterial data or were estimated from observed venous data using deconvolution. Different PD models of acute tolerance as well as non-tolerance were compared.
  • Project 3: Physiological model of HIV dynamics including immune response in order to better understand HIV dynamics and eventually antiretroviral drug effects. Scientific knowledge of several disciplines (immunology, virology, pharmacology) was combined to devise a mathematical model of HIV dynamics to simulate realistic time courses of HIV, infected and non-infected CD4+ Lymphocytes, and CD8+ Lymphocytes, given prior knowledge on the involved parameter distribution. Objectives: 1. Simulation study. 2. Aid in design of future clinical trials.
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10/20/1993   Swiss Federal Diploma of Pharmacy
12/08/1997   PhD in Pharmacology, Faculty of Medicine, University of Berne, Switzerland
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2000   Scientific Assistent, Division of Nephrology, University of Bern.
  • Main Project: Urea kinetics modeling in hemodialysis patients. Improvement of dialysis treatment guidelines by an improved algorithm to predict post-dialysis serum urea concentration rebounds.
2001-2002   Scientific information service for pharmacists, Swiss pharmacists association, Bern
2003-   Clinical pharmacologist in the Modeling & Simulation Group at Hoffmann-La Roche in Basel. Pharmacokinetic and -dynamic modeling and simluation in drug development (focused on oncology)
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Courses and Workshops

01/1997   Technik des wissenschaftlichen Vortrags [Techniques of Scientific Presentations]. H.O Gralky, Freie Universität Berlin. Held in Berne, Switzerland.
11/1996   Forum Gestaltung wissenschaftlicher Poster. University of Berne
06/14−06/15/1996   PAGE meeting (Population Approach Group in Europe). Sandwich, UK
05/19−05/23/1997   Short course and intermediate workshop in population pharmacokinetic data analysis using the NONMEM system. Stewart Beal and L.B. Sheiner, NONMEM Project Group, UCSF. Held in, San Francisco, USA
05/27−05/30/1998   3rd International Symposium on Measurement and Kinetics of in vivo Drug Effects. Leiden University/Vrije Universiteit Amsterdam, The Netherlands. Held in Noordwijkerhout, The Netherlands
04/11−04/16/1999   Workshop on Advanced Pharmacokinetics and Pharmacodynamics. L.B. Sheiner, UCSF, Malcolm Rowland, University of Manchester. Held in San Francisco
06/25−06/26/1999   Workshop on Advanced Methods of Pharmacokinetic/Pharmacodynamic System Analysis. Organized by David Z. D'Argenio, University of Southern California, Biomedical Simulation Resource. Held in Marina del Rey, CA, USA
06/15−06/16/2000   PAGE meeting (Population Approach Group in Europe). Salamanca, Spain
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Computer Skills

Special software   S-Plus, R, NONMEM, Pharsight Trial Simulator (TS2), Berkeley Madonna
UNIX programming   FORTRAN, awk, perl, c-shell script, UNIX text formatting (troff, tbl, eqn, bib), LaTeX, internet: telnet, ftp
DOS/Windows   MS-Office programs, Reference Manager, Mathcad, Internet browsers
NeXTstep   Lighthouse Diagram, SciPlot
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Language Skills

German   mother tongue
English, French   fluent oral and written skills
Spanish   basic communication skills
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Personal Interests

  • Music, member of BernChor21 (choir in Berne) with regular concert performances
  • Hiking, cooking, baking bread, gardening, Yoga
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  • Nicolas Frey, PhD, Head of Modeling & Simluation, Hoffmann-La Roche, 4070 Basel
  • Karin Jorga, PhD, Hoffmann-La Roche, 4070 Basel
  • Dominik E. Uehlinger, MD, Leitender Arzt, Abt. für Nephrologie und Hypertonie, Universität Bern, Inselspital, Freiburgstrasse 10, 3010 Bern, Switzerland
    Tel. +41 (0)31 632 31 44
  • Davide Verotta, PhD, Associate Professor, Depts. Biopharmaceutical Sciences, Epidemiology and Biostatistics, University of California, San Francisco, CA 94143-0446, USA; Tel/fax: +415 476 1556
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© Robert Stark, Bern, 2001-2009. Last Update: look at Home
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